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Across the city, the very first comprehensive retrospective of Gehry work is newly on show on the ground floor of the Pompidou Centre. Gehry doesn like to look backwards. One of its curators, Aurelien Lemonier, walks me around this unpretentious exhibition sixty seven eventful architectural models and 225 drawings, explaining convincingly how, for all his architecture adventure and play, Gehry is an urbanist, a singular architect with a mission to reinvent run down or abandoned city quarters, which is why he pushed hard for the Bilbao Guggenheim to be down in the docks, cheek by concrete jowl with an elevated motorway rather than in some graceful plaza.
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The Eau d’E. coli project aimed to program E. coli to smell like wintergreen during the exponential phase of bacterial growth, when nutrients are plentiful in culture and cells divide exponentially, and like bananas during the stationary phase of growth when nutrients begin to run out and growth slows. Accomplishing this task required several intermediate steps. First canada goose uk shop the team needed to choose a strain of E. coli lacking its native fecal odor so that their odor generators would be detectable. The team chose the strain YYC912, which has a mutation in the tnaA gene responsible for producing the foul smelling molecule indole.
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Now that their odor generators were working canada goose factory sale as expected, the team needed to replace the constitutive promoters with promoters only active during the appropriate phase of cell growth. Recall that the team wanted buy canada goose jacket to officialcanadagoosesoutlet design a system that produces wintergreen odor during exponential phase and banana odor during stationary phase. To accomplish this they fitted their odor generators with growth phase dependent transcriptional devices. For canada goose uk outlet the banana odor generator they used the promoter pOsmY which is switched canada goose coats on during the high osmotic pressure present during stationary phase. Thus, ATF1 and isoamyl acetate are only produced during canada goose coats on sale stationary phase. Their solution for the wintergreen odor generator was a bit different. They again used the pOsmY promoter, but they also added a transcriptional inverter. The inverter reverses the signal of the pOsmY promoter, so that BSMT1 is produced when the pOsmY promoter is turned off during the low osmotic pressure of exponential phase and not produced when the pOsmY promoter is turned on during stationary phase.
Every research project has its bugs. The exponential phase dependent wintergreen odor generator produced methyl salicylate roughly linearly with respect to the density of cells in culture. This matched the trend of the Canada Goose online constitutive promoter, meaning that the exponential phase dependent control device failed to limit isoamyl acetate production to exponential phase.
This is a great example of synthetic biology at Canada Goose Coats On Sale work. Engineering bacterial odor seems like a frivolous pursuit, but there are a number of important direct and indirect applications. In her Canada Goose Parka dissertation, Dr. Shetty pointed online website out that odor engineering could be combined with off gas sampling of bioreactors (which is already common practice) to gain information about bacterial metabolism in an industrial setting very quickly. In a more indirect sense, engineering whole metabolic pathways will certainly be an important component of the anticipated synthetic biology revolution in this century. Programming bacteria to generate useful compounds such as bioplastics often requires extensive metabolic engineering and at the moment remains a tricky business.
Image Credit: canada goose clearance sale Benjah bmm27 and Mschel (via Wikimedia)
References and Further Reading:
MIT 2006 iGEM Team. MIT 2006 iGEM Wiki.
Registry of Standard Biological Parts.
Shetty, R. buy canada goose jacket cheap P. Applying Engineering Principles to the Design and Construction of Transcriptional Devices. Department of Biological Canada Goose Outlet Engineering, MIT (2008).
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